MLPH-mediated activation of dermal papilla IGF-1 signaling drives human hair shaft elongation and anagen induction
These findings support the conclusion that MLPH promotes hair growth via an EPOR-linked, IGF-1-dependent mechanism in DP cells. Future pharmacokinetic and disease-model studies are warranted to evaluate its translational potential.
Authors
- Chang‐Hun Lee (ORCID: https://orcid.org/0000-0002-3806-1170)
- Junsu Kim (ORCID: https://orcid.org/0000-0001-9583-7978)
- Youngheum Ji
- Cheil Moon
- Young Kwan Sung
- Hyeonchang Ju
- Eunho Kang
- Mi Hee Kwack
- So Yeon Kim
Institutions
- Daegu Gyeongbuk Institute of Science and Technology (KR)
- Kyungpook National University (KR)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1016/j.biopha.2026.119114
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00