Effect of a 6-Week Structured Exercise Intervention on TNF-α During the Chronic Recovery Phase of a Burn Injury Compared to Regular Daily Activities: A Pilot Randomised Cross-Over Trial
Fifteen participants completed the protocol with high adherence (90.4%). Exercise significantly improved quadriceps strength and cardiovascular fitness, confirming the intervention's safety and efficacy in this cohort. However, TNF-α concentrations were not elevated at baseline and did not significantly change following exercise compared with control (mean difference: +0.5 pg·mL<sup>-1</sup>, <i>p</i> = 0.249). Exercise is safe and beneficial for non-severely burned patients who sustained their injury > 1 year ago. However, inflammation was not elevated in this cohort, precluding our ability to test the effects of exercise on chronic inflammation.
Authors
- Mark W. Fear (ORCID: https://orcid.org/0000-0003-3163-4666)
- Pippa Kenworthy (ORCID: https://orcid.org/0000-0002-7559-6051)
- Timothy J. Fairchild (ORCID: https://orcid.org/0000-0002-3975-2213)
- Dale W. Edgar (ORCID: https://orcid.org/0000-0001-7336-9317)
- Grant Rowe (ORCID: https://orcid.org/0000-0002-6980-0511)
- Brook Galna
- Brad Wall
- Tyler Jerome Osborne
- Fiona M. Wood (ORCID: https://orcid.org/0000-0001-5427-6588)
Institutions
- Edith Cowan University (AU)
- Murdoch University (AU)
- The University of Western Australia (AU)
- Fiona Stanley Hospital (AU)
- North Metropolitan Health Service (AU)
- Newcastle University (GB)
- The University of Notre Dame Australia (AU)
Publication Details
- Journal
- European Burn Journal
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3390/ebj7010011
- Primary Topic
- Burn Injury Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Murdoch University
- Fiona Wood Foundation