The impact of lipid-rich nutrition on ketogenesis and muscle weakness in sepsis
Pure LCT infusion induced ketosis, but aggravated muscle weakness, which was attenuated by providing supplemental glucose. Combined with glucose, neither long-chain triglycerides nor mixed medium- and long-chain triglycerides were able to induce adequate ketosis or attenuate sepsis-induced muscle weakness.
Authors
- Lies Pauwels
- Sarah Derde (ORCID: https://orcid.org/0009-0005-6724-643X)
- Sarah Vander Perre
- M. Casaer
- Caroline Lauwers (ORCID: https://orcid.org/0000-0001-7278-2708)
- Jan Gunst (ORCID: https://orcid.org/0000-0002-6219-511X)
- Soraya El Dawy
- Inge Derese
- Lies Langouche
- Greet Van den Berghe
Institutions
- KU Leuven (BE)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1186/s40635-026-00867-8
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- KU Leuven
- Vlaamse regering
- HORIZON EUROPE Framework Programme