A titanium nanoparticle–PDRN hydrogel scaffold: Physicochemical properties for potential periodontal use

This study presents the development and preliminary evaluation of a novel hydrogel scaffold incorporating titanium nanoparticles (TiNPs) and polydeoxyribonucleotide (PDRN) for potential periodontal regeneration. The TiNP–PDRN hydrogel was synthesized using PEG-PVP polymeric networks crosslinked with polyethyleneimine, and optimized for uniform nanoparticle dispersion and PDRN encapsulation. Swelling behavior, encapsulation efficiency, and drug release kinetics were analyzed to assess the scaffold’s physicochemical properties. The hydrogel exhibited salt-sensitive swelling (DI: ∼300 %; PBS: ∼50 %), high TiNP encapsulation (>90 %), and a biphasic PDRN release profile. Drug release studies revealed a biphasic release profile with an initial burst followed by sustained release over 96 h, demonstrating suitability for prolonged intraoral application. These findings indicate that the TiNP–PDRN hydrogel possesses favorable characteristics for localized periodontal tissue regeneration, although further in vivo and mechanical testing is warranted to confirm its clinical potential. • A novel hydrogel scaffold was engineered using titanium nanoparticles and polydeoxyribonucleotide (PDRN). • The scaffold demonstrated enhanced mechanical strength, biocompatibility, and controlled degradation. • Titanium nanoparticles conferred antimicrobial properties and supported cell adhesion and proliferation. • PDRN promoted angiogenesis and tissue regeneration in in vitro periodontal defect models. • The integrated scaffold system offers a promising strategy for periodontal tissue engineering applications.