Long‐term follow‐up of chronic central serous chorioretinopathy patients receiving oral eplerenone and half‐dose photodynamic therapy in the SPECTRA trial: SPECTRA trial report No. 4

This study provides evidence for the long-term efficacy of half-dose PDT in resolving SRF and improving functional outcomes in cCSC. Even when patients initially received eplerenone treatment that did not result in complete SRF resolution, crossover treatment with half-dose PDT led to similar (long-term) group outcomes compared to half-dose PDT as initial treatment.

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Publication Details

Journal
Acta Ophthalmologica
Published
2026-02-11
DOI
https://doi.org/10.1111/aos.70106
Primary Topic
Retinal Diseases and Treatments
Type
article
Field-Weighted Citation Impact
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article

Long‐term follow‐up of chronic central serous chorioretinopathy patients receiving oral eplerenone and half‐dose photodynamic therapy in the SPECTRA trial: SPECTRA trial report No. 4

Issam el Mansori, Roula Tsonaka, Roselie M. H. Diederen, Helena M. A. Feenstra et al.
Acta Ophthalmologica
Retinal Diseases and Treatments
article

Long‐term follow‐up of chronic central serous chorioretinopathy patients receiving oral eplerenone and half‐dose photodynamic therapy in the SPECTRA trial: SPECTRA trial report No. 4

Issam el Mansori, Roula Tsonaka, Roselie M. H. Diederen, Helena M. A. Feenstra, Thomas J. van Rijssen, Camiel J. F. Boon, Carel B. Hoyng, Reinier O. Schlingemann, Elon H. C. van Dijk
article en

Abstract

This study provides evidence for the long-term efficacy of half-dose PDT in resolving SRF and improving functional outcomes in cCSC. Even when patients initially received eplerenone treatment that did not result in complete SRF resolution, crossover treatment with half-dose PDT led to similar (long-term) group outcomes compared to half-dose PDT as initial treatment.

Acta Ophthalmologica
Radboud University Nijmegen (NL), Leiden University Medical Center (NL), Radboud University Medical Center (NL), Rotterdam Eye Hospital (NL), Fondation Asile des Aveugles (CH), Amsterdam University Medical Centers (NL), University of Amsterdam (NL)
Openalex Percentile: Top 56%
Retinal Diseases and Treatments
DOIOpen Access PDFOpenAlex
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