An unusual occurrence of a huge ovarian fibroma in a postmenopausal woman impersonating ovarian malignancy: a case report

To report the elusive presentation of a huge ovarian fibroma in a postmenopausal woman, the role of Magnetic Resonance Imaging (MRI) in its evaluation and final diagnosis, with the histopathological examination. A 50-year-old postmenopausal woman presented with a large right ovarian tumour, ascites, and high levels of CA-125. On MRI, the lesion appeared solid to cystic, exhibiting heterogeneous, hypointense-hyperintense signal, with diffusion restriction in the solid component of the mass in diffusion-weighted magnetic resonance (MR) images. A definitive diagnosis of right ovarian fibroma was reached after the histological analysis revealed fascicles and sheets of spindle cells within a collagenized stroma. This case report highlights the atypical and deceptive presentation of ovarian fibroma, emphasizing the challenges in clinical and imaging-based diagnosis.

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Publication Details

Journal
Discover Medicine
Published
2026-02-12
DOI
https://doi.org/10.1007/s44337-026-00564-1
Primary Topic
Ovarian cancer diagnosis and treatment
Type
article
Field-Weighted Citation Impact
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An unusual occurrence of a huge ovarian fibroma in a postmenopausal woman impersonating ovarian malignancy: a case report

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Ovarian cancer diagnosis and treatment
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An unusual occurrence of a huge ovarian fibroma in a postmenopausal woman impersonating ovarian malignancy: a case report

Annapurna Srirambhatla, Aparna Jarathi, Naina Kumar, Syama Sundar Ayya, Ashutosh Rath
article en

Abstract

To report the elusive presentation of a huge ovarian fibroma in a postmenopausal woman, the role of Magnetic Resonance Imaging (MRI) in its evaluation and final diagnosis, with the histopathological examination. A 50-year-old postmenopausal woman presented with a large right ovarian tumour, ascites, and high levels of CA-125. On MRI, the lesion appeared solid to cystic, exhibiting heterogeneous, hypointense-hyperintense signal, with diffusion restriction in the solid component of the mass in diffusion-weighted magnetic resonance (MR) images. A definitive diagnosis of right ovarian fibroma was reached after the histological analysis revealed fascicles and sheets of spindle cells within a collagenized stroma. This case report highlights the atypical and deceptive presentation of ovarian fibroma, emphasizing the challenges in clinical and imaging-based diagnosis.

Discover MedicineVol. 3(1)
Birla Institute of Technology and Science - Hyderabad Campus (IN), All India Institute of Medical Sciences (IN)
Gender equality
Openalex Percentile: Top 59%
Ovarian cancer diagnosis and treatment
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