An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson’s disease
Our study describes a modified synthetic construct that could improve the efficacy of siRNA delivery to deep brain structures and presents proof-of-principle evidence showing that genetic knockdown of NLRP3 could represent a new therapeutic strategy to treat Parkinson's disease and other neuroinflammation-related brain disorders.
Authors
- Frederic Zhentao Li
- Sen Huang
- Yucheng Li (ORCID: https://orcid.org/0009-0008-3054-6684)
- Jiamin Zheng
- Xinghu Du
- Zhizong Li
- Weineng Chen
- Fengjuan Su
- Lishan Lin
- Yu Zhang
- Heng Huang
- Lei Cai
- Zhong Pei
- Hailun Yu
- Huajing You
Institutions
- Sun Yat-sen University (CN)
- Nanjing Drum Tower Hospital (CN)
- ARTS Group (China) (CN)
- Changzhou No.2 People's Hospital (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Nanjing University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1186/s12916-026-04688-0
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00