Prospective Associations of Obesity and Obesity Severity With 9 Cardiovascular Outcomes: The Cross-Cohort Collaboration
Higher BMI was robustly associated with increased risk for most outcomes, particularly HF and AF, even after adjusting for traditional risk factors. Observed sex differences in the relative hazard of higher BMI categories and stroke, total CVD, and all-cause mortality suggest potential differences in underlying biological mechanisms.
Authors
- Yara Jelwan (ORCID: https://orcid.org/0009-0003-9269-7377)
- Semenawit Burka
- Paulo A. Lotufo (ORCID: https://orcid.org/0000-0002-4856-8450)
- Lisa K. Staten (ORCID: https://orcid.org/0000-0002-6056-4153)
- Erfan Tasdighi (ORCID: https://orcid.org/0000-0003-2146-7083)
- Amil M. Shah (ORCID: https://orcid.org/0000-0003-1056-4451)
- Carol A. Derby (ORCID: https://orcid.org/0000-0002-5657-4519)
- Rebecca C. Thurston (ORCID: https://orcid.org/0000-0001-6580-1202)
- Michael E. Hall (ORCID: https://orcid.org/0000-0002-5733-1025)
- Kunal Jha (ORCID: https://orcid.org/0000-0002-3166-9335)
- Giorgos Bakoyannis (ORCID: https://orcid.org/0000-0002-2789-2497)
- Zhiqi Yao (ORCID: https://orcid.org/0000-0001-6356-1524)
- Jianjun Zhang (ORCID: https://orcid.org/0000-0002-8033-6991)
- Isabela M. Bensenor
- Hongmei Nan
- Samar R. El Khoudary
- Joao A.C. Lima
- M J Blaha
- M S B Bittencourt
- Eric S Orwoll
- Bruce M. Psaty
- Debbie L. Cohen
- Amit Khera
- Eleanor M. Simonsick
- Ramachandran S. Vasan
- Peggy M. Cawthon
- Emelia J. Benjamin
- Shelley A. Cole
- Zeina A. Dardari
- Kunihiro Matsushita
- Lawrence J. Appel
- Charles B. Eaton
- Suzanne E. Judd
Institutions
- Rutgers, The State University of New Jersey (US)
- Boston University (US)
- American Heart Association (US)
- Boston Medical Center (US)
- Texas Biomedical Research Institute (US)
- Albert Einstein College of Medicine (US)
- University of Louisville (US)
- Johns Hopkins University (US)
- Oregon Health & Science University (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Pittsburgh (US)
- Brown University (US)
- Johns Hopkins Medicine (US)
- California Pacific Medical Center (US)
- University of Mississippi Medical Center (US)
- University of Alabama at Birmingham (US)
- Department of Health (TW)
- University of Pittsburgh Medical Center (US)
- National Institute on Aging (US)
- Hospital Universitário da Universidade de São Paulo (BR)
- Richard M. Fairbanks Foundation (US)
- The University of Texas at San Antonio (US)
- Indiana University – Purdue University Indianapolis (US)
- University at Buffalo, State University of New York (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Circulation
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1161/circulationaha.125.075327
- Citations
- 1
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 30.73