FOSL1 promotes homologous recombination repair and camptothecin resistance via TCOF1-mediated ribosome biogenesis in non-small cell lung cancer
Our study defines a FOSL1-TCOF1-ribosome axis that promotes CPT tolerance in NSCLC by maintaining HR repair. These findings provide a rationale for targeting ribosome biogenesis to enhance CPT-based treatment and highlight coordinated regulation of transcription, protein synthesis, and DNA repair under chemotherapeutic stress.
Authors
- Chunmei Hao
- Luojun Chen (ORCID: https://orcid.org/0000-0003-4694-8422)
- Qibin Song
- Yi Yao
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Henan Cancer Hospital (CN)
- Hubei Cancer Hospital (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1016/j.tranon.2026.102701
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00