Urine NGAL adds to serum creatinine in predicting cefepime clearance in critically ill children at high risk of acute kidney injury
Integrating uNGAL improves the prediction of cefepime CL beyond SCr alone. Patients with low uNGAL despite elevated SCr risked subtherapeutic exposure. Urine biomarker-guided dosing may help optimise PTA and warrants further study.
Authors
- Tomoyuki Mizuno (ORCID: https://orcid.org/0000-0002-8471-9826)
- Luana Johnson
- Kelli A. Krallman (ORCID: https://orcid.org/0000-0002-3275-2982)
- Calise Curry
- Sonya Tang Girdwood
- Ronaldo Morales Junior
- Stuart L. Goldstein
- H. Rhodes Hambrick
- Michaela Collins
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Lurie Children's Hospital (US)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1016/j.ijantimicag.2026.107741
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00