AmeloD regulates cell proliferation and differentiation process of ameloblasts through modulation of the sonic hedgehog (shh) signaling pathway
AmeloD promotes cell cycle arrest and activation of Shh signaling in the enamel knot, and it binds to Odam in the early stages of ameloblast differentiation, inhibiting the proliferation activity of Odam through these interactions.
Authors
- Sae Oka
- Satoshi Fukumoto (ORCID: https://orcid.org/0000-0002-5046-6891)
- Yuta Hirofuji
- Itaru Komine
- Yuta Chiba
- Mistuki Chiba
- Aya Yamada
- Hiroshi Sato
Institutions
- Kyushu University (JP)
- Kyushu Dental University (JP)
- Tohoku University (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1016/j.job.2026.100758
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00