Bidirectional sleep‐seizure interactions and orexin in a mouse model of tuberous sclerosis complex‐related epilepsy
A bidirectional relationship between seizures and sleep was demonstrated in a mouse model of TSC, with relative seizure frequency surprisingly being highest in REM sleep and seizures causing a disruption of REM sleep. Hypothalamic orexin may partly mediate these seizure-sleep interactions, and orexin antagonists may represent rational therapies for sleep disorders in TSC.
Authors
- Thomas J. Foutz (ORCID: https://orcid.org/0000-0002-0114-0019)
- Lirong Han
- Dongjun Guo
- M H Wong
- Nicholas R. Rensing
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1002/epi.70151
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00