The Total Synthesis of Chlorotricolide: the Top Half

The total synthesis of the top half of chlorotricolide 2, is described. The top half 65 was prepared in 14 steps (10% overall yield) from tartaric acid. The potential usefulness of this top half in the total synthesis of chlorotricolide was demonstrated by connection to bottom half models. Successful deprotection of the α-hydroxy-tetronic acid dimethyl ether moiety is also described. See figures in PDF of thesis.

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Publication Details

Journal
Caltech Library
Published
2026-02-12
DOI
https://doi.org/10.7907/m8zt-ek15
Primary Topic
Vanadium and Halogenation Chemistry
Type
article
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article

The Total Synthesis of Chlorotricolide: the Top Half

Wayne Julius Thompson
Caltech Library
Vanadium and Halogenation Chemistry
article

The Total Synthesis of Chlorotricolide: the Top Half

Wayne Julius Thompson
article en

Abstract

The total synthesis of the top half of chlorotricolide 2, is described. The top half 65 was prepared in 14 steps (10% overall yield) from tartaric acid. The potential usefulness of this top half in the total synthesis of chlorotricolide was demonstrated by connection to bottom half models. Successful deprotection of the α-hydroxy-tetronic acid dimethyl ether moiety is also described. See figures in PDF of thesis.

Caltech Library
California Institute of Technology (US)
Openalex Percentile: Top 58%
Vanadium and Halogenation Chemistry
DOIOpen Access PDFOpenAlex
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The Total Synthesis of Chlorotricolide: the Top Half — Wayne Julius Thompson · Caltech Library (2026) | TGRS Research Map | TGRS