Standardized pre-bronchoscopy mechanical power and KPC resistance as predictors of mortality in ventilated ICU patients: a retrospective cohort study

In critically ill ventilated patients undergoing urgent bronchoscopy, baseline MP under standardized ventilatory conditions did not independently predict outcome. Instead, KPC positivity emerged as the predominant determinant of mortality. These findings underscore the prognostic dominance of microbiological resistance over transient physiologic parameters and highlight the need to integrate rapid resistance profiling with ventilatory monitoring for risk stratification in ICU bronchoscopy critical need to integrate rapid resistance profiling, such as multiplex PCR for resistance gene detection, alongside standardized ventilatory monitoring for early risk stratification and targeted therapeutic intervention in ICU bronchoscopy.