Membrane-proximal binding of PSMA facilitates synapse formation with CAR and enhances antitumor activity of PSMA CAR-T cells against prostate cancer
Targeting the proximal membrane protease domain of PSMA generates functionally superior CAR-T cells. The enhanced efficacy is associated with more robust immunological synapse formation and the concomitant activation of the STING innate immune pathway, offering a novel mechanistic insight for optimizing CAR-T cell design.
Authors
- Feiyang Yan
- Yun Huang (ORCID: https://orcid.org/0000-0003-1549-1669)
- Fengling Wang
- Yalan Zhang
- Xinyu Gu (ORCID: https://orcid.org/0009-0002-7539-8335)
- Weilin Zhou (ORCID: https://orcid.org/0009-0009-2615-6306)
- Haozhan Gao
- Wei Wang
- Shimao Qi
- Jing Li
- Dan Li
- Jiaqian Li
Institutions
- Sichuan University (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1016/j.biopha.2026.119110
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00