Genetic risk stratification and preventive strategies for double primary HNSCC and ESCC: a single-center cohort study
Heavy smoking was associated with the development of LVLs and poor prognosis in those with double primary cancers. ALDH2 and CYP2A6 may contribute to cancer risk, underscoring the importance of abstinence from alcohol and smoking in preventive healthcare.
Authors
- tomohiro umezu
- Masahiko Kuroda (ORCID: https://orcid.org/0000-0001-7052-4289)
- Sakiko Naito (ORCID: https://orcid.org/0000-0002-7533-1061)
- Takao Itoi
- Takashi Morise (ORCID: https://orcid.org/0000-0002-5321-2045)
- Yoshiya Yamauchi (ORCID: https://orcid.org/0000-0003-0834-5866)
- Yasuyuki Kagawa
- Isaku Okamoto
- Masakatsu Fukuzawa
- Hayato Yamaguchi
- Takahiro Muramatsu
- Kiyoaki Tsukahara
Institutions
- Tokyo Medical University (JP)
Publication Details
- Journal
- Esophagus
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1007/s10388-026-01187-2
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00