Discovery of a novel ITPR2::KRAS fusion in large cell neuroendocrine lung cancer: a case report
Upon applying relatively unused RNA-fusion tools, this fused <i>ITPR</i>2::<i>KRAS</i> was not projected to yield a functional protein. This supports that post hoc use of bioinformatics tools may support clinical decision-making for patients when encountering rare genomic alterations, captured by existing diagnostic tests, that would be perceived as highly oncogenic.
Authors
- Allison Makovec (ORCID: https://orcid.org/0009-0008-2487-9079)
- Andrew C. Nelson (ORCID: https://orcid.org/0000-0002-4741-0010)
- Paweł Mróz (ORCID: https://orcid.org/0000-0003-3838-4743)
- Justin H. Hwang (ORCID: https://orcid.org/0000-0003-1686-7103)
- David Moline
- Anthony Patregnani
- Robert A. Kratzke
- Rejowana Rouf
- Gabriella von Dohlen
Institutions
- University of Minnesota (US)
- University of Kansas (US)
- Twin Cities Orthopedics (US)
- University of Minnesota Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.21037/tlcr-2025-aw-1328
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00