Murine Aortopulmonary Shunt Model of Flow-Driven Pulmonary Hypertension—Brief Report
Transcatheter aortopulmonary shunt establishes a minimally invasive, reproducible murine model of shunt-driven pulmonary artery hypertension triggered by flow-mediated arteriopathy. This platform provides a versatile tool to interrogate flow-sensing mechanisms and to evaluate therapies targeting both vasoreactivity and structural remodeling in pulmonary artery hypertension.
Authors
- Ken Fujise
- Dunpeng Cai
- Shi-You Chen
- Ruimei Zhou
Institutions
- Harborview Medical Center (US)
- Harry S. Truman Memorial Veterans' Hospital (US)
- University of Missouri (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1161/atvbaha.125.323657
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00