Homozygous Myo7A mutation associations teratozoospermia and intracytoplasmic sperm injection failure in humans and mice

Our findings indicate that <i>Myo7a</i> gene defects affect sperm function by combining dysregulation of key structural proteins such as DPY19L2, FSIP2, DNAH8 and DNAH17. Fertilisation disorders caused by <i>Myo7a</i> can be overcome by AOA + ICSI. The study provides novel insights into the role of <i>Myo7a</i> during sperm development across species and advances the understanding of teratozoospermia mechanisms.

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Publication Details

Journal
Translational Andrology and Urology
Published
2026-02-01
DOI
https://doi.org/10.21037/tau-2025-474
Primary Topic
Sperm and Testicular Function
Type
article
Field-Weighted Citation Impact
0.00

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article

Homozygous Myo7A mutation associations teratozoospermia and intracytoplasmic sperm injection failure in humans and mice

Longlong Fu, Huijuan Liao, Xiaoyong Qiao, Keyu Ren et al.
Translational Andrology and Urology
Sperm and Testicular Function
article

Homozygous Myo7A mutation associations teratozoospermia and intracytoplasmic sperm injection failure in humans and mice

Longlong Fu, Huijuan Liao, Xiaoyong Qiao, Keyu Ren, Leixi Peng, Chengyu Wu, Y S Yang, Jinhong Li, Shan Luo, Yantong Zheng, Yu Bai, Lang Qin, Di Ouyang
article en

Abstract

Our findings indicate that <i>Myo7a</i> gene defects affect sperm function by combining dysregulation of key structural proteins such as DPY19L2, FSIP2, DNAH8 and DNAH17. Fertilisation disorders caused by <i>Myo7a</i> can be overcome by AOA + ICSI. The study provides novel insights into the role of <i>Myo7a</i> during sperm development across species and advances the understanding of teratozoospermia mechanisms.

Translational Andrology and UrologyVol. 15(2)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Sichuan University (CN), National Health and Family Planning Commission (CN), West China Second University Hospital of Sichuan University (CN), West China Hospital of Sichuan University (CN)
Massachusetts Department of Agricultural Resources, Sichuan University
Openalex Percentile: Top 60%
Sperm and Testicular Function
DOIOpen Access PDFOpenAlex
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Homozygous Myo7A mutation associations teratozoospermia and intracytoplasmic sperm injection failure in humans and mice — Longlong Fu, Huijuan Liao, et al. · Translational Andrology and Urology (2026) | TGRS Research Map | TGRS