Neoantigen Vaccine Spurs Broad Immune Responses

A neoantigen vaccine against 209 frameshift peptides elicited strong, broad, and long-lasting immunity in people with Lynch syndrome in a phase Ib/II study, offering a novel approach for preventing the range of cancers these individuals are at an elevated risk of developing.

Publication Details

Journal
Cancer Discovery
Published
2026-02-11
DOI
https://doi.org/10.1158/2159-8290.cd-nw2026-0012
Primary Topic
Genetic factors in colorectal cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Neoantigen Vaccine Spurs Broad Immune Responses

Cancer Discovery
Genetic factors in colorectal cancer
article

Neoantigen Vaccine Spurs Broad Immune Responses

article en

Abstract

A neoantigen vaccine against 209 frameshift peptides elicited strong, broad, and long-lasting immunity in people with Lynch syndrome in a phase Ib/II study, offering a novel approach for preventing the range of cancers these individuals are at an elevated risk of developing.

Cancer Discovery
Good health and well-being
Openalex Percentile: Top 59%
Genetic factors in colorectal cancer
DOISourceOpenAlex
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Neoantigen Vaccine Spurs Broad Immune Responses · Cancer Discovery (2026) | TGRS Research Map | TGRS