Electrospun Composite <i>Lavandula Angustifolia</i> Mill. Extract/PVP Nanofibers

ABSTRACT Background : Lavandula angustifolia Mill. is widely used for its potential health benefits. It has antimicrobial, anti‐inflammatory, and wound‐healing properties due to the presence of both terpenoids and phenolic compounds. Novel formulations for both oral and topical usage could extend the range of applications. Methods : In this study, electrospun nanofibers incorporating dry extract of lavender (at 9.09%, 16.67%, and 24.98% w/w) were prepared using polyvinylpyrrolidone (PVP) as a polymer matrix, with the aim of creating fast‐dissolving systems. Results : Fibers produced at 10 kV exhibited uniform morphology, with the 9.09% w/w lavender extract ratio showing the optimum morphology (average diameters: 0.70–1.49 µm). The obtained fibers were smooth, uniform, free of beads, and comprised amorphous solid dispersions. All the fiber formulations rapidly disintegrated and accelerated the dissolution of lavender extract. Conclusions : These findings highlight the potential of lavender extract‐loaded nanofibers as fast‐acting delivery systems. This work provides a novel approach for formulating medicinal plant‐loaded nanofibers, especially for active ingredients with low solubility, and offers a potential therapy for wound healing.