Bibliometric and Data Mining Analysis of Research Trends in Multiple Sclerosis with a Focus on Complementary and Alternative Medicine (CAM)

Introduction: Multiple sclerosis (MS) is a multifactorial autoimmune disease that has garnered increasing attention for the use and efficacy of complementary and alternative medicine (CAM) in its management. Due to its complex and chronic nature, MS requires a comprehensive and multidimensional therapeutic approach in which CAM may play a supportive role in improving patients’ quality of life . Method: This study employs bibliometric and data mining methods to examine research trends, key topics, and conceptual developments in MS -related CAM studies. It aims to map the thematic structure, keyword evolution, and scholarly progress in this interdisciplinary field. Data were extracted from the Web of Science database and analyzed using advanced tools such as SciMAT and Biblioshiny. Scientific mapping, thematic clustering, and trend analysis were conducted across two time periods: 2011 –2015 and 2016 – 2020. Hierarchical clustering and keyword dendrograms were utilized to identify core research themes . Results: The findings identified key areas of research, including herbal medicine, dietary interventions, yoga, mindfulness, saturated fatty acids, interleukin -4, evening primrose oil, breathing exercises, and cannabinoids. A significant number of MS patients report using CAM therapies alongside conventional treatments, citing notable benefits. Hierarchical clustering revealed three major thematic clusters: saturated fatty acids, inflammation and CAM, and rehabilitative therapies. Moreover, the adoption of CAM therapies and their impact on patient care have shown a growing trend, while emerging topics such as phytoestrogens and oligodendrocytes gained prominence . Conclusion: Bibliometric analysis in the fields of MS and CAM enhances the current understanding of therapeutic practices and paves the way for future clinical and academic research. This study highlights the importance of integrative, multidisciplinary, and patient - centered approaches in healthcare, guiding researchers toward emerging topics and more effective treatment strategies for MS patients.