Integrated application of Raman spectroscopy in traumatic brain injury: A systematic review and clinical perspective
RS distinguished injured from control tissue through spectral changes reflecting protein and lipid alterations and differentiated lesion areas by revealing astrogliosis-related reorganization. Instantaneous in-situ RS devices achieved >92% accuracy in severity classification and detected biomarker-related molecular changes. Point-of-care RS platforms using lateral flow strips enabled rapid detection of specific TBI biomarkers (GFAP, NAA, NSE, S100B, UCH-L1), showing performance comparable to ELISA while offering faster, simpler, and cost-efficient testing.
Authors
- Anca Onaciu
- Luca David
- Valentin Toma (ORCID: https://orcid.org/0000-0001-8322-1180)
- Cristian Moldovan (ORCID: https://orcid.org/0000-0003-2927-4622)
- R. Borsa (ORCID: https://orcid.org/0009-0007-1754-2681)
- Adela Golea (ORCID: https://orcid.org/0000-0002-7227-2326)
- Gabriela-Fabiola Știufiuc
- Rares-Ionut Stiufiuc
- George-Teo Voicescu
- Eugenia-Maria Lupan-Mureșan
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Babeș-Bolyai University (RO)
Publication Details
- Journal
- Experimental Neurology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1016/j.expneurol.2026.115677
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00