Low‐Intensity Pulsed Ultrasound Alleviation of LPS‐Induced Depression‐Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation

LIPUS mitigates LPS-induced neuroinflammation, neuronal apoptosis, and depression-like behavior by targeting microglial P2X4R and activating the BDNF/TrkB pathway. The findings provide mechanistic insights and demonstrate that LIPUS is a promising non-pharmacological intervention for depression, underscoring the translational potential of P2X4R as a therapeutic target.

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Publication Details

Journal
CNS Neuroscience & Therapeutics
Published
2026-02-01
DOI
https://doi.org/10.1002/cns.70786
Primary Topic
Vagus Nerve Stimulation Research
Type
article
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article

Low‐Intensity Pulsed Ultrasound Alleviation of LPS‐Induced Depression‐Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation

Xinyi Zhang, Yuanli WANG, Hongwu Zhan, Paul K. Chu et al.
CNS Neuroscience & Therapeutics
Vagus Nerve Stimulation Research
article

Low‐Intensity Pulsed Ultrasound Alleviation of LPS‐Induced Depression‐Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation

Xinyi Zhang, Yuanli WANG, Hongwu Zhan, Paul K. Chu, Chengbiao Ding, Deli Yang, Xinyue Meng, Wanke Zou, Mianzhi Zhang, Ruilin Chen
article en

Abstract

LIPUS mitigates LPS-induced neuroinflammation, neuronal apoptosis, and depression-like behavior by targeting microglial P2X4R and activating the BDNF/TrkB pathway. The findings provide mechanistic insights and demonstrate that LIPUS is a promising non-pharmacological intervention for depression, underscoring the translational potential of P2X4R as a therapeutic target.

CNS Neuroscience & TherapeuticsVol. 32(2)
Sun Yat-sen University (CN), City University of Hong Kong (HK), Anhui Medical University (CN), Zhuhai People's Hospital (CN), Fifth Affiliated Hospital of Sun Yat-sen University (CN), Second Affiliated Hospital of Anhui Medical University (CN)
Good health and well-being
Openalex Percentile: Top 65%
Vagus Nerve Stimulation Research
DOIOpen Access PDFOpenAlex
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Low‐Intensity Pulsed Ultrasound Alleviation of LPS‐Induced Depression‐Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation — Xinyi Zhang, Yuanli WANG, et al. · CNS Neuroscience & Therapeutics (2026) | TGRS Research Map | TGRS