Pathways from Polygenic Risk to Suicidality: Effects of Alcohol Use Disorder and Childhood Adversity
Genetic liability to SA operates partly through AUD, particularly among individuals with lower childhood adversity. Under higher adversity, alternative pathways to SA likely predominate. These findings highlight the need to consider distinct etiological pathways to the development of suicidality and the relevance of AUD as a modifiable target for suicide prevention among individuals at high genetic liability.
Authors
- C. E. Davis
- Richard Feinn (ORCID: https://orcid.org/0000-0002-4158-7640)
- Xuejun Qin (ORCID: https://orcid.org/0000-0001-9411-9034)
- Anna R. Docherty
- Victoria Wu
- Henry Kranzler
- Allison Ashley-Koch
- Joel Gelernter
Institutions
- Huntsman (United States) (US)
- Duke University (US)
- University of Utah (US)
- Spencer Foundation (US)
- Durham VA Health Care System (US)
- Philadelphia VA Medical Center (US)
- Durham VA Medical Center (US)
- VA Mid-Atlantic Health Care Network (US)
- Quinnipiac University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-12
- DOI
- https://doi.org/10.64898/2026.02.10.26345999
- Primary Topic
- Suicide and Self-Harm Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Eli Lilly and Company
- Office of Research and Development
- National Institute of Mental Health
- NIH Clinical Center