Melanin as a Redox Hub: Linking Energy Flow to Genome Stability and Immune Control
Targeting pigment chemistry itself, through NOS inhibition, denitrosylation, and triplet-state quenching, offers a compelling translational strategy to suppress dCPDs, rebalance redox signaling, and restore immune function. Coupling these interventions to quantitative biomarkers of pigment oxidation, nitrosylation networks, and chemiexcitation activity may enable patient stratification and rational therapeutic sequencing, transforming melanin from a risk modifier into an actionable redox interface. <i>Antioxid. Redox Signal.</i> 44, 618-635.
Authors
- Sanjay Premi (ORCID: https://orcid.org/0000-0002-5492-5469)
- Jyoti Srivastava (ORCID: https://orcid.org/0000-0003-3922-9526)
Institutions
- Moffitt Cancer Center (US)
Publication Details
- Journal
- Antioxidants and Redox Signaling
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1177/15230864261421542
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Melanoma Research Alliance
- Moffitt Cancer Center
- National Institutes of Health
- National Cancer Institute