Achilles Tendon Xanthoma Inflammation Revealed by FDG-PET/CT in Familial Hypercholesterolemia

These findings show that xanthomas exhibit persistent metabolic activity despite short-term lipid lowering, whereas prolonged therapy may attenuate inflammation. Phenotypic differences underscore roles of disease stage, cumulative lipid exposure, and treatment duration. FDG-PET/CT provides metabolic information for risk assessment and therapeutic monitoring.

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Publication Details

Journal
JACC Case Reports
Published
2026-02-12
DOI
https://doi.org/10.1016/j.jaccas.2026.106949
Primary Topic
Histiocytic Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Achilles Tendon Xanthoma Inflammation Revealed by FDG-PET/CT in Familial Hypercholesterolemia

Takaharu Nakayoshi, Yayoi Sakata, Nobuhiro Tahara, Y F Fukumoto et al.
JACC Case Reports
Histiocytic Disorders and Treatments
article

Achilles Tendon Xanthoma Inflammation Revealed by FDG-PET/CT in Familial Hypercholesterolemia

Takaharu Nakayoshi, Yayoi Sakata, Nobuhiro Tahara, Y F Fukumoto, Shuichi Tanoue
article en

Abstract

These findings show that xanthomas exhibit persistent metabolic activity despite short-term lipid lowering, whereas prolonged therapy may attenuate inflammation. Phenotypic differences underscore roles of disease stage, cumulative lipid exposure, and treatment duration. FDG-PET/CT provides metabolic information for risk assessment and therapeutic monitoring.

JACC Case ReportsVol. 31(11)
Kurume University (JP)
Good health and well-being
Openalex Percentile: Top 56%
Histiocytic Disorders and Treatments
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