24-hour ex vivo perfusion of vascularized composite allografts in a large animal total limb model
Twenty-four-hour swine hindlimb perfusion preserved ATP, morphology, and function. Perfusion prevented ATP depletion and mitigated muscle damage compared with SCS, supporting its potential to extend VCA preservation. Transplant studies are warranted.
Authors
- Çağdaş Duru (ORCID: https://orcid.org/0000-0002-6453-0508)
- Felor Biniazan (ORCID: https://orcid.org/0009-0009-6337-0205)
- Alina Stoian (ORCID: https://orcid.org/0000-0002-6138-5579)
- Golnaz Karoubi
- Shaf Keshavjee
- Florian LeBillan
- Siba Haykal
Institutions
- University Health Network (CA)
- Yale University (US)
Publication Details
- Journal
- Frontiers in Transplantation
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/frtra.2026.1718484
- Primary Topic
- Organ and Tissue Transplantation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00