Pre-Radioiodine Thyrotropin Thresholds During Withdrawal Preparation in Differentiated Thyroid Cancer after Total Thyroidectomy: A Systematic Review and Meta-Analysis
The current evidence base is insufficient to support or refute the routine use of a specific TSH threshold before RAI administration. These findings question the recommendation to achieve TSH ≥30 mIU/L before RAI and highlight the need for trials to define the minimal effective level of TSH stimulation.
Authors
- Francisco J. Barrera-Flores
- Luís Reyes (ORCID: https://orcid.org/0000-0003-1209-7535)
- Juan Pablo Brito (ORCID: https://orcid.org/0000-0003-1840-1745)
- Benjamin Alvarado-Mafla (ORCID: https://orcid.org/0000-0001-5526-6840)
- Camila Pazmino-Chavez
- Tannya Ledesma
- Eduardo Pilatuña (ORCID: https://orcid.org/0000-0001-9547-2630)
- María Belén Tite-Haro (ORCID: https://orcid.org/0000-0001-7416-6167)
- Paola Solis-Pazmino
- Jason Cohen
- Yosef Nasseri
- Tatiana Rojas
- David Toro-Tobon
- Oscar J. Ponce
Institutions
- Mayo Clinic (US)
- Harvard University (US)
- Central University of Ecuador (EC)
- Derriford Hospital (GB)
- Massachusetts General Hospital (US)
- Facultad Latinoamericana de Ciencias Ecuador (EC)
- Mayo Clinic in Florida (US)
- Special Service for Groups (US)
- University Hospitals Plymouth NHS Trust (GB)
- Universidad San Francisco de Quito (EC)
Publication Details
- Journal
- Thyroid
- Published
- 2026-02-11
- DOI
- https://doi.org/10.1177/10507256261423206
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00