A novel GIPR/GLP-1R dual agonist improves systemic metabolism through differentially regulating inflammation and lipid metabolism in obesity
Both GLP-1R and GIPR are important in mediating the beneficial effects of dual receptors on systemic metabolism. THDBH120 is a novel long-acting dual GIPR/GLP-1R agonist that has potential clinical applications.
Authors
- Fang Hu
- Ruitang Cheng
- Chen Zhinan
- Zhiqiang Du
- Huiying Wang
- Yan Qiu
- Wei R. Chen
- Dan Wu
- Lijun Xie
- Zhiguang Zhou
- Jinying Hu
- Tian Li
- Feng Zhang
Institutions
- Central South University (CN)
- Tianjin Nankai Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Shanghai Changning Mental Health Center (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jare.2026.02.006
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00