Morpho-Functional Characterization and miRNA Profiling of the Retina in the 5xFAD Murine Model of Alzheimer's Disease
The present findings confirm and expand our knowledge of the retinal disease in 5xFAD mice, and highlight that neuroinflammation, oxidative stress, and microgliosis participate in AD pathogenesis. The relationship between deregulated miRNAs and AD progression may open the field to miRNA-based strategies to slow down retinal dysfunction in AD.
Authors
- Francesca Corsi (ORCID: https://orcid.org/0000-0002-9350-7948)
- Silvia Marracci (ORCID: https://orcid.org/0000-0002-0730-2648)
- Rosario Amato (ORCID: https://orcid.org/0000-0002-8386-4714)
- Lorenzo Guidotti (ORCID: https://orcid.org/0009-0000-8335-4821)
- G. Casini (ORCID: https://orcid.org/0000-0002-0270-4437)
- Massimo Dal Monte (ORCID: https://orcid.org/0000-0002-5181-4456)
- Martina Lucchesi (ORCID: https://orcid.org/0009-0006-8825-142X)
- Maurizio Cammalleri (ORCID: https://orcid.org/0000-0001-8934-5838)
- Eleonora Daghini
- Giuseppe Neri
- Claudia Gargini
- Ugo Borello
Institutions
- University of Pisa (IT)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1167/iovs.67.2.31
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00