Network pharmacological and experimental validation of the mechanism of Chaihu Guizhi Ganjiang decoction regulating T helper cell 17/regulatory T cell balance to improve autoimmune hepatitis.

This study demonstrated the therapeutic effect of CGGD on AIH through a combination of network pharmacological prediction and experimental validation. Its mechanism of action involves PI3K/Akt/ NF-κB-mediated regulation of Th17/Treg cells.

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Publication Details

Journal
PubMed
Published
2026-02-01
DOI
https://doi.org/10.19852/j.cnki.jtcm.2026.01.010
Primary Topic
Liver Diseases and Immunity
Type
article
Field-Weighted Citation Impact
0.00
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article

Network pharmacological and experimental validation of the mechanism of Chaihu Guizhi Ganjiang decoction regulating T helper cell 17/regulatory T cell balance to improve autoimmune hepatitis.

Jinyun Song, Zihao LIANG, Jie GAO, Qin ZHENG et al.
PubMed
Liver Diseases and Immunity
article

Network pharmacological and experimental validation of the mechanism of Chaihu Guizhi Ganjiang decoction regulating T helper cell 17/regulatory T cell balance to improve autoimmune hepatitis.

Jinyun Song, Zihao LIANG, Jie GAO, Qin ZHENG, Hongyu Zhao
article en

Abstract

This study demonstrated the therapeutic effect of CGGD on AIH through a combination of network pharmacological prediction and experimental validation. Its mechanism of action involves PI3K/Akt/ NF-κB-mediated regulation of Th17/Treg cells.

PubMedVol. 46(1)
Nanjing University of Chinese Medicine (CN), Nanjing Second Hospital (CN)
Good health and well-being
Openalex Percentile: Top 57%
Liver Diseases and Immunity
DOIOpen Access PDFOpenAlex
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Network pharmacological and experimental validation of the mechanism of Chaihu Guizhi Ganjiang decoction regulating T helper cell 17/regulatory T cell balance to improve autoimmune hepatitis. — Jinyun Song, Zihao LIANG, et al. · PubMed (2026) | TGRS Research Map | TGRS