Global, regional, and national burden of schizophrenia: epidemiological trends, decomposition, joinpoint analysis, and projections to 2036 based on GBD 2021
While schizophrenia currently exerts a disproportionately higher burden on young and middle-aged males, our projections indicate a notable epidemiological shift, with females expected to experience a steeper rise in incidence, prevalence, and DALYs over the next 15 years. This emerging female-centric trend contrasts sharply with the current male-dominated profile, underscoring the urgent need for sex-responsive mental health strategies.
Authors
- Donglian Li (ORCID: https://orcid.org/0009-0005-7850-2005)
- Gang Chen (ORCID: https://orcid.org/0000-0002-8320-6594)
- Jiujie He
- Liwen Wang (ORCID: https://orcid.org/0009-0001-1004-5291)
- Jian Dai
- Zongyu Li
- Kejun Wu
- Wanting Zhou
- Lishuo Wu
- Yi Yang
Institutions
- Guangxi Medical University (CN)
- Guangxi University of Chinese Medicine (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Riverside Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fpsyt.2026.1702808
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00