Pharmacokinetics of colistin in adult critically ill patients in South Africa
Our results are comparable to previously published literature. Notably, increasing eGFR and WCC decreased colistin AUC. Future work will adopt a population pharmacokinetic modelling approach to quantify and account for sources of variability, with the aim of informing individualized dosing strategies for this South African population.
Authors
- R. Davids
- Daniel Mashishi
- Arifa Parker (ORCID: https://orcid.org/0000-0002-2005-698X)
- Ahmed Aliyu Abulfathi (ORCID: https://orcid.org/0000-0002-2089-3614)
- Veshni Pillay-Fuentes Lorente (ORCID: https://orcid.org/0000-0001-5365-0320)
- Tamsin Lovelock (ORCID: https://orcid.org/0000-0002-3730-1646)
- Jocelyn de Jong
- Kessendri Reddy
- Usha Lalla (ORCID: https://orcid.org/0000-0002-4395-5152)
- Eric H. Decloedt (ORCID: https://orcid.org/0000-0003-1815-5150)
- Tracy Kellermann (ORCID: https://orcid.org/0000-0003-1542-4976)
- Adrie Bekker
- Julien S Marais
- Roland Van Rensburg
Institutions
- Western Cape Department of Health (ZA)
- Stellenbosch University (ZA)
- Certara (United States) (US)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1093/jac/dkag011
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00