Lactobacillus paracasei LP18 ameliorated inflammation and intestinal barrier dysfunction in severe acute pancreatitis via gut microbiota-mediated regulation of butyrate metabolism
<i>Lactobacillus paracasei</i> LP18 attenuates SAP-associated intestinal inflammation and barrier dysfunction, primarily through modulation of gut microbial composition, restoration of butyrate-associated metabolic profiles, and suppression of NF-κB-related inflammatory signaling.
Authors
- Jianliang Cao
- Xinya Jia
- Lan C
- Tangjuan Zhang
- Bo Li (ORCID: https://orcid.org/0009-0006-5799-1134)
- Qiang Zhang (ORCID: https://orcid.org/0000-0002-5857-327X)
- Yuepeng Hu
- Anran Song
Institutions
- National Cerebral and Cardiovascular Center (JP)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fmicb.2026.1765127
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00