Integrative diagnosis of invasive pulmonary aspergillosis in non-neutropenic patients using BALF-tNGS–derived Aspergillus load and host risk factors: a multicenter study
Integrating BALF-tNGS-derived normalized <i>Aspergillus</i> reads with host factors substantially improves differentiation of IPA from colonization in non-neutropenic patients. This semi-quantitative framework supports early, individualized antifungal decision-making and merits external validation.
Authors
- Bofei Liu (ORCID: https://orcid.org/0000-0003-4417-3694)
- W. Chen
- Jianjun Wang (ORCID: https://orcid.org/0000-0001-7039-7136)
- Jinyuan Zhu (ORCID: https://orcid.org/0000-0001-8637-1336)
- Yonghong Yang (ORCID: https://orcid.org/0000-0002-8423-1652)
- Feng Tao (ORCID: https://orcid.org/0000-0002-8259-0803)
- Furui Liu
- Wenyan Zhou
- Ying Yang
- Zhifeng Wang
Institutions
- Ningxia Hui Autonomous Region Peoples Hospital (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Wuxi Third People's Hospital (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fcimb.2026.1739837
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China