Higher proximity of PD-L1+ tumor cells to PD-1+ tissue-resident memory CD8 determines response to neoadjuvant chemoimmunotherapy in non-small cell lung cancer
T cells interacting with PD-L1<sup>+</sup> tumor cells may be characterized as PD-1<sup>+</sup> CD8<sup>+</sup> T<sub>RM</sub> cells. A closer distance between the two enhances therapeutic efficacy and may be associated with density of hypoxic CD8 cells.
Authors
- Qianhui Chen (ORCID: https://orcid.org/0009-0002-6651-9684)
- Yushan Yan
- Jiaxiao Geng
- Liying Yang
- Xiaorong Sun
- Fanghan Cao
- Miaoqing Zhao
- Ligang Xing
- Hao Yang
- Li Wu
- Hongtu Yuan
- Yimin Zhao
Institutions
- Shandong University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Shandong Tumor Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.21037/tlcr-2025-aw-1259
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project
- Key Technology Research and Development Program of Shandong