Hippocampal atrophy and functional plasticity underlie cognitive outcome in anti‐leucine‐rich glioma‐inactivated protein 1 encephalitis and their clinical correlates
Our findings reveal a dual neural mechanism underlying cognitive outcome in anti-LGI1 encephalitis: the hippocampal atrophy correlates with cognitive deficits, whereas enhanced left hippocampal-mOFC connectivity represents a compensatory plastic response. Early immunotherapy may promote this beneficial plasticity, highlighting these structural and functional signatures as potential biomarkers for stratifying patients and monitoring therapeutic efficacy.
Authors
- Shuang Wang (ORCID: https://orcid.org/0000-0002-4351-2116)
- Sha Xu (ORCID: https://orcid.org/0000-0001-8987-4940)
- Hongxia Li (ORCID: https://orcid.org/0000-0002-1440-1345)
- Bing‐Qing Du
- Yinxi Zhang (ORCID: https://orcid.org/0000-0002-4462-171X)
- Shan Wang (ORCID: https://orcid.org/0000-0002-6238-2644)
- Cong Chen (ORCID: https://orcid.org/0000-0003-0875-7473)
- Rui Li
- Yue Hu (ORCID: https://orcid.org/0000-0002-9814-0233)
- Yi‐He Chen
- Yi Ge (ORCID: https://orcid.org/0009-0009-1408-2864)
- Xi‐Peng Long
- Xiao‐Tong Shao
- Yu‐Yu Yang
- Hao Song
- Chun‐Hong Shen
- Yi Guo
- Chen‐Min He
- Mei‐Ping Ding
- Shi‐Yu Geng
- Chen‐An Xu
- Yao Ding
- Zi‐Jian Wang
Institutions
- Zhejiang Cancer Hospital (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Epilepsia
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1002/epi.70141
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Medical Science and Technology Project of Zhejiang Province
- Science and Technology Program of Zhejiang Province