Dimeric Furanones with a Unique Polycyclic Spiro Skeleton from Hawk Tea
Six novel furanone derivatives, hawktealide A-F (<b>1</b>-<b>6</b>), featuring a novel 5/6/5 tricyclic system containing with a spiro-ring, were isolated from hawk tea. The structures of these compounds were confirmed using high-resolution electrospray ionization mass spectrometry (HR-ESIMS), nuclear magnetic resonance (NMR), electronic circular dichroism (ECD), and single-crystal X-ray diffraction data. Compounds <b>1</b>-<b>3</b> showed concentration-dependent cytotoxicity against AsPC-1 and HCT-116 cells. Compound <b>1</b> was notably more potent against AsPC-1 cells than against HCT-116 or L02 cells. Further experiments revealed that compound <b>1</b> induced autophagy, inhibited migration, and caused cell cycle arrest in AsPC-1 cells.
Authors
- M. Zhang
- Shiji Xiao
- Lang Huang (ORCID: https://orcid.org/0000-0002-6728-9510)
- Yan Meng (ORCID: https://orcid.org/0000-0001-7313-1181)
- Guanqun Liang (ORCID: https://orcid.org/0000-0003-2819-3599)
- Yuhe Wang (ORCID: https://orcid.org/0000-0002-2267-698X)
- Minjian Kong Aiqiang Dong
- Chengxin Sun
- Yike Fang
- Xinye Qiu
- Dale Guo
- Yilin Wu
Institutions
- Central South University (CN)
- Southwest University (CN)
- Zunyi Medical University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Shaanxi Research Association for Women and Family (CN)
- Second Xiangya Hospital of Central South University (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1021/acs.joc.5c02725
- Primary Topic
- Tea Polyphenols and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00