Cross-talk between lipopolysaccharide tolerance and AGEs in the regulation of macrophage inflammation and cholesterol efflux
These findings demonstrate that LPS tolerance promotes an atheroprotective macrophage phenotype characterized by attenuated inflammatory signaling and enhanced cholesterol efflux. However, this protective immunometabolic program is selectively disrupted by AGE exposure, highlighting a critical interface through which chronic metabolic stress may override innate immune tolerance and contribute to atherosclerotic progression.
Authors
- S. Ariga
- Denise Frediani Barbeiro (ORCID: https://orcid.org/0000-0001-6802-8120)
- Monique de Fátima Mello Santana (ORCID: https://orcid.org/0000-0002-7380-0696)
- Sayonara Assis (ORCID: https://orcid.org/0000-0001-7202-5192)
- Francisco García Soriano (ORCID: https://orcid.org/0000-0003-4898-0135)
- Eduarda Palanca
- Marisa Passarelli
- Danielle Ribeiro Santos
- Milena Gomes Vancini
- Aritania Sousa Santos
- Maria Lucia Correa-Giannella
Institutions
- Universidade Nove de Julho (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fimmu.2026.1669028
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico