Metabolism-corrected propofol exposure intensity and long-term intelligence quotient in pediatric febrile infection-related epilepsy syndrome: a retrospective cohort study
Practice-driven propofol exposure significantly impairs long-term cognition in a dose-dependent manner in FIRES, with accelerated neurotoxicity beyond 2,000 mg/kg. This threshold should prompt a mandatory multidisciplinary review and consideration of alternative treatment options.
Authors
- Feng Gao (ORCID: https://orcid.org/0000-0003-0397-7493)
- Xiaoming Wu
- Haowei Li (ORCID: https://orcid.org/0009-0001-6385-376X)
- Fengzhan Chen
- Xiaoyan Wang
- Lin Yan
- Jianhang Chen
- Baohua Wang
Institutions
- Qingdao University (CN)
- Taizhou Second People's Hospital (CN)
- Qingdao Women and Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fmed.2026.1747795
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00