Effects and interactive effects of high-altitude environment on metabolism in normal and diabetic populations: a comparative metabolomics study
Our comprehensive metabolomic analysis reveals distinct metabolic perturbations in T2DM patients under high-altitude conditions, highlighting guanosine as a unique biomarker for identifying altitude-related diabetic metabolic dysregulation. These findings advance our understanding of the pathophysiological mechanisms underlying T2DM in high-altitude environments and provide a potential diagnostic target for clinical management of diabetic populations in such regions.
Authors
- Hengyan Li
- Yongyue Guo
- Yunhong Wu
- Jinli Meng
- Wanlin He (ORCID: https://orcid.org/0009-0009-1775-9156)
- CHENGHUI ZHANG
- Xiaomei Li
- Li Feng (ORCID: https://orcid.org/0000-0001-7658-1399)
- Xin Hu
- Jian Cheng
- Suyuan Wang
- Jing Shi
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Tibet Autonomous Region People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fendo.2026.1736270
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00