Epigenetic activation of SLC7A11 defines a ferroptosis—immune axis and enables robust DNA methylation-based diagnosis of lung squamous cell carcinoma
SLC7A11 undergoes epigenetic activation in LUSC and enables a robust four-probe, methylation-based diagnostic model. Its expression is linked to ferroptosis resistance, immune evasion, and therapeutic response, supporting SLC7A11 as a promising biomarker for early diagnosis and personalized treatment in LUSC.
Authors
- Xiao Li (ORCID: https://orcid.org/0000-0001-9785-4907)
- Dongming Li (ORCID: https://orcid.org/0000-0002-0085-5653)
- Guoying Ni (ORCID: https://orcid.org/0000-0002-7410-5900)
- Zhiqiang Chen (ORCID: https://orcid.org/0000-0001-6590-739X)
- Jiandi Li
- Yi-wu Dang
- Hui-ping Lu
- Yulu Tang
- Yiyang Chen
- Lingling Pang
- Gang Chen
- Qi Li
- Kesong Nong
- Liangqin Zhu
- Jingwen Ling
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2026-02-12
- DOI
- https://doi.org/10.7717/peerj.20686
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangxi Province
- Guangxi Medical University
- Division of Graduate Education