Clinicopathological features of hepatobiliary cells in primary biliary cholangitis patients with incomplete response to ursodeoxycholic acid

PBC patients with an incomplete response to UDCA exhibited a significant increase in CK7⁺ HB cells, which were independently associated with treatment incomplete response. Although biochemical parameters such as ALP and TBA remain key predictors of incomplete response to UDCA, CK7⁺ HB cells provide additional histological insights into the mechanisms underlying incomplete therapeutic response.