MTG2 as a Causal and Druggable Target in Uveal Melanoma via Mitochondrial DNA Dynamics: Evidence From Functional Validation and DMSA Identification
Our integrative genomic and experimental approach uncovers MTG2 as a causal contributor to UM pathogenesis, potentially through modulation of mtDNA heteroplasmy and copy number. DMSA emerges as a promising therapeutic agent targeting mitochondrial dysregulation in UM.
Authors
- Changzhou Feng
- Daliu Min (ORCID: https://orcid.org/0000-0001-9589-4032)
- Wenxi Yu (ORCID: https://orcid.org/0000-0002-0391-4196)
- Yu Wang (ORCID: https://orcid.org/0000-0003-3151-0778)
- Bowen Cui
- Yan Zhang
- Yuying Su
- Zan Shen
Institutions
- Xuzhou Medical College (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Medical Center (CN)
- The First People’s Hospital of Lianyungang (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1167/iovs.67.2.30
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00