Intermittent ketogenic fasting with medium-chain triglycerides improves ataxia in COQ8A-related coenzyme Q10 deficiency: A case report
This case highlights the potential of ketogenic intermittent fasting as an adjunct therapy for mitochondrial ataxia. Ketogenic intermittent fasting was associated with clinically meaningful improvement of ataxia in a patient with COQ8A-related CoQ10 deficiency, suggesting that ketogenic dietary strategies may represent a promising adjunct therapeutic approach for mitochondrial ataxia. Future research should assess this intervention in larger patient cohorts to confirm its potential benefits.
Authors
- Felix Zahnert (ORCID: https://orcid.org/0000-0003-0366-6724)
- Karla Erffmeier
- Wiebke Hahn (ORCID: https://orcid.org/0000-0002-7002-6551)
- Maximilian Schulze (ORCID: https://orcid.org/0000-0001-5996-948X)
- Susanne Knake
- Panagiota-Eleni Tsalouchidou
Institutions
- Philipps University of Marburg (DE)
- National and Kapodistrian University of Athens (GR)
Publication Details
- Journal
- Molecular Genetics and Metabolism Reports
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1016/j.ymgmr.2026.101296
- Primary Topic
- Coenzyme Q10 studies and effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00