PKC-iota drives EGFR-TKI resistance in EGFR-mutated NSCLC by phosphorylating FASN to reprogram lipid metabolism
Our study elucidates a mechanism of EGFR-TKI resistance mediated by the PKC-iota/FASN axis through reprogramming lipid metabolism in EGFR-mutated NSCLC, which provides a novel therapeutic target for overcoming EGFR-TKI resistance and improving the prognosis of EGFR-mutated NSCLC patients.
Authors
- Siyue Song (ORCID: https://orcid.org/0000-0003-2389-7503)
- X Chen
- Sun Q (ORCID: https://orcid.org/0009-0009-1281-278X)
- Yumei Chen
- Liu Liu
- Wenhui Xie
- Lin Ma
- Yingwen Han
- Lunran Xu
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Chest Hospital (CN)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.21037/tlcr-2025-aw-1260
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00