Avapritinib improves cutaneous involvement in patients with indolent systemic mastocytosis: Results from the randomized, phase 2, interventional PIONEER study
Avapritinib treatment improved dermatologic symptoms, decreased skin lesion size, normalized skin lesion color, and reduced skin mast cell burden in patients with ISM.
Authors
- Johanna Ungerstedt (ORCID: https://orcid.org/0000-0002-0202-7296)
- J. Gotlib
- Sonia Cerquozzi (ORCID: https://orcid.org/0000-0001-9027-1776)
- Scott F. Florell
- Ilda Bidollari
- Anton Rets (ORCID: https://orcid.org/0000-0002-2148-162X)
- K. Hartmann
- Sigurd Broesby‐Olsen (ORCID: https://orcid.org/0000-0002-1558-8471)
- Mariana Castells (ORCID: https://orcid.org/0000-0001-6451-0163)
- Ingunn Dybedal (ORCID: https://orcid.org/0000-0002-3229-3069)
- A Ivan
- Hui‐Min Lin
- Janet Hong
- Mark Rafferty
- C. Bulai Livideanu
- Vito Sabato
- Philippe Schafhausen
- Tracy I. George
- David A. Wada
- Paul van Daele
- Cem Akin
- Benjamin Lampson
- Stéphane Barete
- Jens Panse
- Deepti H. Radia
- Princess U. Ogbogu
- Daniel J. DeAngelo
- Celalettin Ustun
- Frank Siebenhaar
- Andreas Reiter
- Daniel Shaheen
Institutions
- Oslo University Hospital (NO)
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- Harvard University (US)
- University of Antwerp (BE)
- Universität Hamburg (DE)
- University of Calgary (CA)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- University of Utah (US)
- Heidelberg University (DE)
- University of Michigan (US)
- Beatson West of Scotland Cancer Centre (GB)
- Huntsman Cancer Institute (US)
- Odense University Hospital (DK)
- Erasmus MC (NL)
- University Hospital Heidelberg (DE)
- University Hospital of Basel (CH)
- Karolinska Institutet (SE)
- Humboldt-Universität zu Berlin (DE)
- Sorbonne Université (FR)
- Düsseldorf University Hospital (DE)
- Hospital Virgen del Valle (ES)
- Assistance Publique – Hôpitaux de Paris (FR)
- Blueprint Medicines (United States) (US)
- Antwerp University Hospital (BE)
- University Medical Center Hamburg-Eppendorf (DE)
- Dana-Farber Cancer Institute (US)
- Universitätsklinikum Aachen (DE)
- Pitié-Salpêtrière Hospital (FR)
- Hôpital Larrey (FR)
- Rainbow Babies & Children's Hospital (US)
- Heinrich Heine University Düsseldorf (DE)
- RWTH Aachen University (DE)
- Stanford University (US)
Publication Details
- Journal
- Journal of the American Academy of Dermatology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jaad.2026.02.025
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00