Integrated Clinical Genetic Analysis Reveals Transcriptional Neurotransmitter Receptor Dysregulation in Meningiomas Causing Seizure
Here, we show that seizure causing meningiomas demonstrate distinct clinical, radiographic, chromosomal, and transcriptional features. Novel associations with seizure presentation in meningioma include MenG C status, chromosome 14q loss, and seizure-specific dysregulation of neurotransmitter receptor genes.
Authors
- Sean K. Lau (ORCID: https://orcid.org/0000-0003-0805-0056)
- Shervin Hosseingholi Nouri (ORCID: https://orcid.org/0009-0002-9454-6700)
- Diego Rojas (ORCID: https://orcid.org/0000-0002-5388-1070)
- Rajan S. Patel (ORCID: https://orcid.org/0000-0002-0265-2446)
- Kumar Pichumani
- Malcolm F. McDonald (ORCID: https://orcid.org/0000-0002-2627-9754)
- Kalman A. Katlowitz
- G.V. Rao
- Akash Patel (ORCID: https://orcid.org/0000-0001-9351-5764)
- Ali Jalali
- Tiemo J Klisch
- Collin English
- Akdes S. Harmanci
- A. Basit Khan
Institutions
- Houston Methodist (US)
- Baylor College of Medicine (US)
- Methodist Hospital (US)
- Neurological Research Institute (US)
- Texas Children's Hospital (US)
- University of Oklahoma (US)
Publication Details
- Journal
- Neurosurgery
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1227/neu.0000000000003931
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 0.00