Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulator of tumor immune features and of the KRAS pathway
In summary, cholesterol uptake emerges as a conserved driver of tumor aggressiveness and a promising therapeutic target to synergize with immunotherapy and KRAS inhibition.
Authors
- Jorge Gonçalves (ORCID: https://orcid.org/0000-0002-3045-2150)
- Jessica Roelands (ORCID: https://orcid.org/0000-0003-3631-2041)
- Joana Carvalho (ORCID: https://orcid.org/0000-0002-4405-3302)
- Ana Luísa Machado (ORCID: https://orcid.org/0000-0001-6487-0679)
- Luísa Pereira (ORCID: https://orcid.org/0000-0001-5709-7550)
- Verónica Fernandes
- Sérgia Velho
- N. F. C. C. Miranda
- Ana Pinto
- Maria José Oliveira
Institutions
- Instituto Superior de Contabilidade e Administracao do Porto (PT)
- Universidade do Porto (PT)
- Leiden University Medical Center (NL)
- IPO Porto (PT)
- Rede de Química e Tecnologia (PT)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1007/s13402-026-01171-z
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00